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Year : 2016  |  Volume : 2  |  Issue : 1  |  Page : 29-35

Comparative antiplasmodial evaluation of Cymbopogon citratus extracts in Plasmodium berghei-infected mice

Department of Science Laboratory Technology, University of Jos, Jos, Nigeria

Correspondence Address:
David Arome
Department of Science Laboratory Technology, University of Jos, Jos
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2455-3069.184126

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Background: As malaria is still an important life-threatening infection in many tropical countries and drug resistance has become increasingly common to drugs used nowadays, there is a pressing need to find more drugs that may contribute to the reduction of malaria in the future. This calls for an inward look into harnessing the full potential of medicinal plants that abound around us. Objective: To evaluate the antiplasmodial activity of aqueous leaf and root extracts of Cymbopogon citratus against Plasmodium berghei in mice. Materials and Methods: Cymbopogon citratus extracts of 200, 400, 800 mg/kg, and 5 mg/kg of chloroquine were used. Antiplasmodial activity of the extracts was evaluated using 4-day suppressive test model. Results: The extracts exhibited significant (P < 0.05) antiplasmodial activity in all the experimental doses used. The aqueous leaf extract produced a percentage suppressive effect of 20.83%, 55.56%, and 80.56% while that of the root extract produced a percentage suppression of 50.38%, 77.78%, and 100%. The suppressive effect of the extracts followed a dose-dependent pattern with 800 mg/kg of the aqueous root extract having the highest activity and producing the same 100% suppressive effect as chloroquine. In addition, the extracts had a mild effect on the body temperature of the infected mice; there was a significant increase only on the 2 nd day of the study. Conclusion: The results of the study suggested that the aqueous root extract possesses a better antiplasmodial activity than the aqueous leaf extract.

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