• Users Online: 590
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2020  |  Volume : 6  |  Issue : 2  |  Page : 152-154

Neuroendocrine neoplasm of liver with intratumoral discordance of mitotic and Ki-67 proliferation index

Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry, India

Correspondence Address:
Bakiarathana Anand
20, 1st Floor, Thirumurugan Street, Kamaraj Nagar, Puducherry - 605 011
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrsm.jcrsm_15_20

Rights and Permissions

A 70-year-old female presented with backache and was found to have multiple lesions in the liver along with additional lesions in the sacral bone, adrenal, and the tail of pancreas. Six computed tomography-guided core biopsies from single lesion in the liver showed a neoplasm composed of small cells with fairly uniform, round nuclei and granular eosinophilic cytoplasm arranged around dilated vascular channels. Mitotic index was 3/10 high-power fields. A suspicion of neuroendocrine neoplasm (NEN) was confirmed by positive immunohistochemistry for synaptophysin. The Ki-67 proliferation index was 30%–40%. These findings confirmed metastatic NEN in the liver with intratumoral discordance in mitotic index of Grade 2 and Ki-67 proliferation index of Grade 3 according to the WHO 2017 grading of gastroenteropancreatic NEN. The discordance between primary and secondary NEN is known; however, the discordance of mitotic and Ki-67 index within the same tumor is unusual and hence we report this case.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded100    
    Comments [Add]    

Recommend this journal